Medications reach maximal adherence in synergy.
These two emotional states may look equal despite the mechanism of action being of different contexts.
Self-identifying is of hormonal origin, mainly adrenergic.
Empathy is of brain-circuitry origin, a kind of personality.
Autistics score high on self-identifying.
Endorphins overdrive is the most common reaction normally leading to meltdown in distressing situations.
It is established that adrenaline’s release through endorphins is contagious and autists have highlighted senses causing them to absorb it all.
Hormones play a pivotal role.
As for reward, we all crave for it: reward enhances dopamine and serotonin, the ‘feel good’ neurotransmitters.
These chemicals are often dysfunctional in autism.
Hormones affect neurotransmission to a varying degree.
In my experience, I don’t feel rewarded most of the time.
Off-label treatment is showing promising results, although the placebo effect cannot be ruled out.
Acetylcholine is the main neurotransmitter present at all body s nerve endings.
It plays a key-role in memory, motility, metabolism.
All neurotransmitters are somehow dependent to acetylcholine.
Anticholinergic therapy mimics the model of action of antidepressants by blocking neurotransmission at pre-synaptic level.
Latest research shows anticholinergic optimal response in combination with antihistamines and benzodiazepines.
In hot-humid climates, anticholinergics are widely employed in Motion-sickness by targeting Neuronal-displacement, coincidentally responsible for autistic meltdown.
In my experience, they have calming and non-sedating properties.
Specific categories of drugs peak efficacy in synergy.
Meds’ info generally highlights Warnings of “potential interactions” or “no interactions reported”, thus far creating further apprehension among users.
It is important to understand what the targets of drugs are.
- Anticholinergics: acetylcholine
- Antidepressants: serotonin, dopamine, noradrenaline
- Benzodiazepines: G.A.B.A.
- Antihistamines: mast cells’ histamine released in response to allergic reactions
These compounds interact safely.
We know that most current medication cures symptoms, not the original disease.
We must identify where the symptoms originate in order to understand interactions, what meds-info will never tell you.
The Internet is all the more misleading and partial with countless medical ads.
Medical textbooks are mostly reliable.
Let’s start with Acetylcholine:
Acetylcholine is the final product of the Parasympathetic Nervous System.
That would explain the anticholinergics’ enhancement of anti-allergens like antihistamines.
For this reason, Acetylcholine is also referred to as neuromodulator.
Needless to say, the parasympathetic nervous system reverts allergic reactions triggered by the sympathetic nervous system.
Humoral neurotransmitters:
Serotonin, Dopamine and Noradrenaline are released by brain synapses following an electric impulse through neurons.
Cerebral electric-activity determines functional neurotransmission and mood.
Antidepressants increase humoral neurotransmitters activity.
G.A.B.A.
Benzodiazepines enhance Antidepressants targeting the calming neurotransmitter GABA.
GABA in turn, is highly involved in the regulation of electrical nerve impulses.
See the interaction of benzodiazepines with electric-activity and anticonvulsants in the cure of epilepsy, an electric signals dysfunction.
Benzodiazepines increase GABA activity.
Histamine:
Histamine is released by mast cells present throughout the body.
Their function is to fight inflammation.
Inflammation is the response to allergens affecting mainly skin, airways and gastrointestinal tract.
The controversy of histamine is that it exacerbates inflammation.
Antihistamines block histamine release.
Their mechanism of action is not fully understood: they are potentially drowsy, sedating, enhancing all aforementioned compounds.
For this reason they are often used off-label in mental health.
Speculation that mental illness may be an allergic reaction is taken into consideration.
