Idiosyncratic Reactions in ADHD

ADHD is highly co-morbid with Autism. It is characterized by Paralysis Worry.

ADHD is characterized by dysfunctional Dopamine and Adrenaline transmission.
Contrary to the logic, these rewarding neurotransmitters are deficient at pre-synaptic level, while stationary at receptor-level.

The Hyperactivity associated to ADHD is a Craving for Dopamine and Adrenaline, NOT an Excess, as popularly endorsed by ignorant, sadistic, old Millennial teachers which my generation had the disgust of knowing.
I apologize to young educated teachers, I strive hard to come to terms with, although 20 years of abuse and humiliation leave the mark.

ADHD was the curse of all teachers, back in the day.
The timeframe was the 80/90 s, ndr.
Teachers didn’t have any basic Mental Health skills, ADHDers were seen as diabolically possessed, literally: we were called “Children of Satan” and treated accordingly, at least in my country.
My predisposition to humanities is what saved me.
My Maths professor would have made for a Master Exorcist!

I do have issues with PTSD as well, you ll understand. It always gets in the way, out of control.
It is hard to stay on topic with ADHD, but I give free will to my mind, prior to typing guidelines. I’m not pretending, just being me.

So, back to the top.
Neurotransmission takes place between releasing cells, synapses and receiving cells, so-called Receptors.
The process must be interchangeable and continuous, henceforth regulated by the Autonomous Nervous System.
Once again, we cure the symptoms, not the disease.

In ADHD, dopamine and adrenaline are not re-uptaken in the releasing cells, they remain trapped in the receptors and ineffective.
That explains why Stimulants have a calming impact in ADHD by increasing dopamine and adrenaline at pre-synaptic level.
Speculation is that Humoral Neurotransmitters are active at releasing cells-level only.
Receptors would be the recharge-pools of dormant neurotransmitters.
Stimulants target Adrenal glands in order to manufacture extra dopamine and adrenaline.

Put it bluntly, we function on Stimuli.
By law of physics, Energy can only be released by ignition and absorbed.
Absorption gradually decreases energy, unless Re-uptaken and fired again.
This is the functional neurotransmission pattern.

 Idiosyncratic reactions are common in the brain.

“Idiosyncratic” refers to “Opposite, Atypical”, in Medical.

GABA is popularly known as the calming neurotransmitter by regulating nerve impulses. It has the potential of blocking the release of dopamine and adrenaline. 
If taken into consideration the ‘Release Effect’, it would be an enemy in ADHD.
If taken into consideration the ‘Pre-synaptic Effect’, it would be a blessing.
These two mechanisms of action are not yet clear.
Personally, I m in favour of the Release Effect.

Paralysis Worry is the medical term for Procrastination, or Overthinking.
ADHDers are good at taking cold decisions, whilst faulty at decision-making as result of low self-esteem. This is literally paralysing. Worry is the subconscious precursor. At this stage, it is easy to imagine the efficacy of stimulants.

Stimming is a visible feature of Paralysis Worry, a repetitive, unproductive nervous tic like tapping hands or feet.
How influential is OCD in ADHD?
They are indeed repetitive compulsions, with the exception that OCD ultimately releases anxiety, whereas Stimming can be permanent.