Extreme Hot/Cold temperatures can cause Mental and Physical pain. They also affect how meds work. The best results are achieved by the right Combination of agonist and antagonist compounds under the circumstances.

Pain is always unpleasant, let’s not sugarcoat it, whether physical or emotional.
The neurodivergent may be more aware of Emotional Pain, whereas I believe in one pain alone.
Possibly, it can be exacerbated.
Weather is just one of the triggers that affects everyone.

Meteoropathy is not a diagnosis, it’s a condition related to weather changes that cause physical and mental illness in general. Related diagnoses range from Arthritis to Agoraphobia, in the initial stages. 

Arthritis is the tension of muscles in order to generate heat, mainly in the head, neck and shoulders. The downside is that muscle-tension causes inflammation and pain at nerve endings. Humidity is responsible to similar symptoms in hot weather.

Agoraphobia is the fear of open spaces, not necessarily a meteoropathy, though it can be exacerbated accordingly. 
This is the Mental component, nobody wants to go out in freezing or scorching temperatures.

The stereotype is that Dopamine works better in cold environments, Opioids in hot weather.
Unfortunately, idiosyncrasies are common.
Latest research shows improved efficacy of agonist and antagonist medications taken in conjunction.

The Autonomous Nervous System is virtually our worst enemy if not modulated by the Sympathetic and Parasympathetic Nervous Systems.
The agonist and antagonist pharmacological models work in synergy with the Sympathetic and Parasympathetic Systems.

The myth of increasing the specific medication when ineffective is being challenged. We all have a ‘breaking point’, after which additional dosage is either expelled from the body by the Immune System, or accounts for overdose, unproductive and potentially fatal.

The winning strategy is abating the antagonists.
Freezing temperatures release dopamine in conjunction with melatonin, the notorious Sleep Hormone, pushing us into hibernation mode, therefore inhibiting dopamine, worst scenario for ADHD First Responders… the more dopaminergics we assume, the more melatonin is released!

Neural modulation makes the difference. 
GABA is a modulating neurotransmitter with the potential of blocking melatonin and dopamine in excess.
GABA is a natural, harmless chemical, acting on antagonistic signals by never depleting essential chemicals, available over the counter and my first choice.
Acetylcholine is another potent neuromodulator and main neurotransmitter present at all body s nerve endings. It comes in the form of Anticholinergic supplements.
Antihistamines are also effective for allergic reactions. 
Opioids are strong tranquilizers and painkillers, they give optimal protection in combination with stimulants. They are controlled substances, therefore require a prescription.
Our bodies react differently under the same circumstances.
Many factors are associated to Winter low-mood. Generally speaking, Light, Darkness, Cold climate. However, symptoms can vary individually.

With Winter and the shortest days of the year, comes punctually the dreaded ‘Hibernation-mode’.
This term summarizes the whole Winter symptomatology. Nobody is exempt, though in different ways, either positively or negatively.

Statistics show a significant number of individuals who dread Hot Weather.
It is scientifically proven that the Cold stimulates dopamine, good news for ADHDers and Emergency workers, to mention some.

Now, nobody is comfortable with Freezing temperatures, henceforth our Sympathetic Nervous System responds by releasing extra Melatonin from the Pineal Gland even in conditions of daylight, putting us in Hibernation-mode in order to warm up the body.

Melatonin is the Sleep-hormone normally released at night.
Problem is, the sun sets in late afternoon during Winter months, well before the end of the average Working Day, around 4pm globally.

Dopamine and Melatonin become antagonists in nature, one making us alerted, the other sleepy, no-doubt perfect for stay-at-home individuals with insomnia.
This group accounts for Winter lovers.

Altogether, I still favour Winter as a First Responder with ADHD. 
Sweltering Summers deplete me of dopamine fast through hyperhydrosis.
It goes without saying that Mild temperatures are ideal for all, a thing of the Past when we had 4 seasons. Nowadays, we only have Winter and Summer, putting tremendous pressure on the body.

Melatonin synthesis is oversimplified as the ‘sleep hormone released at night.’
In reality, it is one of the most complex mechanisms.
To start with, it is questionable whether Melatonin acts at hormone or neurotransmitter level, since it’s a byproduct of Serotonin.
Other neurotransmitters and pinealocytes are envolved, primarily Norepinephrine and GABA, typically antagonists: the former a trigger, the latter a modulator.
The Pineal gland receives and conveys messages to the SCN-Suprachiasmatic Nucleus-by Photoreception, the processing of Light and Darkness at retinal level: in the absence of Light, norepinephrine signals the SCN to release Melatonin, in the presence of Light the SCN secretes GABA which inhibits the release of Melatonin.

The SCN is permanently connected to the earthly 24 hrs day-cycle, thus determining the body s Circadian Rhythm regardless to light or darkness. 
People living at the Earth s poles know it all too well: Winters have permanent darkness, Summers permanent light. The pressure on the body and mind is extreme however, the body recognizes Noon and Midnight either in Winter or Summer.

The best remedy for Seasonal affective disorders is following the natural Circadian-Rhythm as strictly as possible.

Melatonin and GABA supplements are available over-the-counter and helpful for each season.